2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Urea Transporter

Urea Transporter

Urea Transporter

Urea transporters (UTs) are transmembrane urea-selective channels expressed in multiple tissues. UT proteins, including UT-A in kidney tubule epithelia and UT-B in vasa recta microvessels, facilitate urinary concentrating function.
The UT-A gene family contains at least six isoforms, generated by alternative splicing, with the largest isoform being UT-A1. UT-A1 and UT-A3 are expressed in the kidney inner medullary collecting duct, and UT-A2 in the thin descending limb of Henle in both inner and outer medulla.
UT-B is mainly expressed in endothelial cell membrane of the renal medulla and in other tissues, including the brain, heart, pancreas, colon, bladder, bone marrow, and cochlea. UT-B is responsible for the maintenance of urea concentration, male reproductive function, blood pressure, bone metabolism, and brain astrocyte and cardiac functions. Its deficiency and dysfunction contribute to the pathogenesis of many diseases.

Urea Transporter Related Products (2):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-128129
    UT-B-IN-1
    		Inhibitor 99.68%
    UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research.
    UT-B-IN-1
  • HY-155642
    PU-48
    		Inhibitor 99.64%
    PU-48 is a potent urea transporters A (UT-A) inhibitor (IC50=0.32 μM). PU-48 has a good diuretic effect in mouse models, and shows little or no cytotoxicity. PU-48 has the potential to be developed as a diuretic.
    PU-48