Urea Transporter

Urea transporters (UTs) are transmembrane urea-selective channels expressed in multiple tissues. UT proteins, including UT-A in kidney tubule epithelia and UT-B in vasa recta microvessels, facilitate urinary concentrating function.
The UT-A gene family contains at least six isoforms, generated by alternative splicing, with the largest isoform being UT-A1. UT-A1 and UT-A3 are expressed in the kidney inner medullary collecting duct, and UT-A2 in the thin descending limb of Henle in both inner and outer medulla.
UT-B is mainly expressed in endothelial cell membrane of the renal medulla and in other tissues, including the brain, heart, pancreas, colon, bladder, bone marrow, and cochlea. UT-B is responsible for the maintenance of urea concentration, male reproductive function, blood pressure, bone metabolism, and brain astrocyte and cardiac functions. Its deficiency and dysfunction contribute to the pathogenesis of many diseases.

References:

[1]. Yu L, et al. Physiological functions of urea transporter B. Pflugers Arch. 2019 Dec;471(11-12):1359-1368. doi: 10.1007/s00424-019-02323-x. Epub 2019 Nov 22.

[2]. Levin EJ, et al. Structure and permeation mechanism of a mammalian urea transporter. Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11194-9. [Content Brief]

[3]. Esteva-Font C, et al. A small molecule screen identifies selective inhibitors of urea transporter UT-A. Chem Biol. 2013 Oct 24;20(10):1235-44. [Content Brief]

Urea Transporter Inhibitors (8)

Urea Transporter Related Products (9):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-155642

PU-48	Inhibitor	99.76%
PU-48 is a potent urea transporters A (UT-A) inhibitor (IC₅₀=0.32 μM). PU-48 has a good diuretic effect in mouse models, and shows little or no cytotoxicity. PU-48 has the potential to be developed as a diuretic.

HY-128129

UT-B-IN-1	Inhibitor	99.68%
UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC₅₀ values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research.

HY-183637

E822-1968	Inhibitor
E822-1968 is an UT-A2 inhibitor with a human IC₅₀ of 0.44 μM. E822-1968 blocks urea transport mediated by UT-A2. E822-1968 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.

HY-183636

M353-0039	Inhibitor
M353-0039 is a selective UT-A2 inhibitor with a human IC₅₀ of 0.35 μM. M353-0039 blocks urea transport mediated by UT-A2. M353-0039 can be used for the study of hyponatremia and edema associated with congestive heart failure, nephrotic syndrome, and cirrhosis.

HY-121132

Butibufen	Inhibitor
Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation.

HY-116718

UTA1inh-D1	Inhibitor
UTA1inh-D1 is a selective UT-A1 and UT-B urea transporter inhibitor with IC₅₀ values of 3.8 μM and 15 μM, respectively. UTA1inh-D1 is promising for research of refractory edema, such as congestive heart failure and cirrhosis.

HY-W702634

Butibufen-d₅
Butibufen-d₅ is the deuterium labeled Butibufen (HY-121132). Butibufen is an orally active non-steroidal compound. Butibufen shows analgesic and antipyretic properties. Butibufen can be used for the research of inflammation.

HY-124107

UTA1inh-A1	Inhibitor
UTA1inh-A1 is a urea transporter (UT) inhibitor. UTA1inh-A1 has IC₅₀ values of 3.3 μM and 16 μM for UT-A1 and UT-B. UTA1inh-A1 can be used in research related to urearetics.

HY-131382

UTA1inh-C1	Inhibitor
UTA1inh-C1 is a urea transporter (UT-A) inhibitor with IC₅₀ of 4.2 μM.

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